LY3502970 (Orforglipron) | GLP-1 agonist | Probechem Biochemicals

Chemical Structure : LY3502970

CAS No.: 2212020-52-3

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LY3502970 (Orforglipron, OWL-833, LY-3502970)

货号: PC-72211Not For Human Use, Lab Use Only.

LY3502970 (Orforglipron, OWL-833) is a potent, selective, orally active non-peptide agonist of glucagon-like peptide-1 (GLP-1) receptor.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥3980	In stock
250 mg		Get quote

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生物&药学活性

LY3502970 (Orforglipron, OWL-833) is a potent, selective, orally active non-peptide agonist of glucagon-like peptide-1 (GLP-1) receptor.
LY3502970 is a partial agonist, biased toward G protein activation over β-arrestin recruitment at the GLP-1R.

物理化学性质&存储条件

分子量	882.974
分子式	C48H48F2N10O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (8.8 mg/mL)
Chemical Name/SMILES	3-((1S,2S)-1-(5-((S)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-2-((S)-3-(3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-indol-1-yl)-2-methylcyclopropyl)-1,2,4-oxadiazol-5(4H)-one

参考文献

1. Kawai T, et al. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29959-29967.

2. Cong Z, et al. Nat Commun. 2021 Jun 18;12(1):3763.

LY3502970 (Orforglipron, OWL-833, LY-3502970)

生物&药学活性

物理化学性质&存储条件

参考文献

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LY3502970 (Orforglipron, OWL-833, LY-3502970)

生物&药学活性

物理化学性质&存储条件

参考文献

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