Muvalaplin (LY3473329) | Lipoprotein (a) inhibitor | Probechem Biochemicals

Chemical Structure : LY3473329

CAS No.: 2565656-70-2

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LY3473329 (Muvalaplin, LY-3473329)

货号: PC-20057Not For Human Use, Lab Use Only.

LY3473329 (Muvalaplin) is a potent, specific, multivalent, orally active disruptor/ inhibitor of lipoprotein(a) (Lp(a)) formation, binds to Kringle IV (KIV)8 domain selectively with a potency of 22 nM and inhibits the formation of Lp(a) particles in vitro with IC50 value of 0.09 nM.

规格	价格	库存
2 mg	￥2480	In stock
5 mg	￥3980	In stock
10 mg	￥5880	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

LY3473329 (Muvalaplin) is a potent, specific, multivalent, orally active disruptor/ inhibitor of lipoprotein(a) (Lp(a)) formation, binds to Kringle IV (KIV)8 domain selectively with a potency of 22 nM and inhibits the formation of Lp(a) particles in vitro with IC50 value of 0.09 nM.

LY3473329 (Muvalaplin) reduced the levels of Lp(a) with an absolute ED50 of 3 mg kg−1, with a maximum Lp(a) reduction of 92% after five days of BID oral dosing in Lp(a) transgenic mouse model.

LY3473329 (Muvalaplin) is a potent and specific orally administered agent for reducing the levels of Lp(a).

物理化学性质&存储条件

分子量	710.90
分子式	C42H54N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,2'S,2''S)-3,3',3''-((nitrilotris(methylene))tris(benzene-3,1-diyl))tris(2-((R)-pyrrolidin-3-yl)propanoic acid)

参考文献

1. Diaz N, et al. Nature. 2024 May 8. doi: 10.1038/s41586-024-07387-z.

LY3473329 (Muvalaplin, LY-3473329)

生物&药学活性

物理化学性质&存储条件

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LY3473329 (Muvalaplin, LY-3473329)

生物&药学活性

物理化学性质&存储条件

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