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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Antifolate-LY345899
LY345899

Chemical Structure : LY345899

CAS No.: 10538-99-5

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LY345899 (LY-345899, LY 345899)

货号: PC-70211Not For Human Use, Lab Use Only.

LY345899 (LY 345899) is a novel potent, cytoplasmic and mitochondrial methylenetetrahydrofolate dehydrogenase MTHFD1 and MTHFD2 inhibitor with IC50 of 96 nM and 663 nM, respectively.

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5 mg ￥2380 In stock
10 mg ￥3880 In stock
25 mg ￥5780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY345899 (LY 345899) is a novel potent, cytoplasmic and mitochondrial methylenetetrahydrofolate dehydrogenase MTHFD1 and MTHFD2 inhibitor with IC50 of 96 nM and 663 nM, respectively.
MTHFD2 is a novel target for drug development.

物理化学性质&存储条件

分子量 471.43
分子式 C20H21N7O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(3-amino-1-hydroxy-9-oxo-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl)-L-glutamic acid

参考文献

1. Tedeschi PM, et al. Mol Cancer Res. 2015 Oct;13(10):1361-6.

2. Gustafsson R, et al. Cancer Res. 2017 Feb 15;77(4):937-948.

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