LY344864 | 5-HT1F agonist | Probechem Biochemicals

Chemical Structure : LY344864

CAS No.: 186544-26-3

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LY344864 (LY 344864)

货号: PC-49006Not For Human Use, Lab Use Only.

LY344864 is a potent, selective agonist of 5-HT1F receptor with Ki value of 6 nM, with little to no affinity for other serotonergic and non-serotonergic neuronal binding sites.

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10 mg	￥980	In stock
25 mg	￥1780	In stock
50 mg	￥2980	In stock
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生物&药学活性

LY344864 is a potent, selective agonist of 5-HT1F receptor with Ki value of 6 nM, with little to no affinity for other serotonergic and non-serotonergic neuronal binding sites.
LY344864 inhibited forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors with EC50 of 3 nM.
Oral and intravenous LY344864 administration potently inhibited dural protein extravasation caused by electrical stimulation of the trigeminal ganglion in rats.
LY 344864 decreased the number of capsaicin-induced c-fos-like immunoreactive cells within trigeminal nucleus caudalis (ID50=0.6 mg/kg).

物理化学性质&存储条件

分子量	351.425
分子式	C21H22FN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide

参考文献

1. Phebus LA, et al. Life Sci. 1997;61(21):2117-26.

2. Mitsikostas DD, et al. Eur J Pharmacol. 1999 Mar 26;369(3):271-7.

3. Cohen ML, et al. J Pharmacol Exp Ther. 1999 Sep;290(3):935-9.

LY344864 (LY 344864)

生物&药学活性

物理化学性质&存储条件

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LY344864 (LY 344864)

生物&药学活性

物理化学性质&存储条件

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