LY3358966 | NaPi2b inhibitor | Probechem Biochemicals

Chemical Structure : LY3358966

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LY3358966 (LY 3358966)

货号: PC-73330Not For Human Use, Lab Use Only.

LY3358966 is a potent, selective inhibitor of the intestinal sodium‐dependent phosphate cotransporter NPT2b (NaPi-2b, SLC34A2), inhibits phosphate uptake in human NPT2b expressed in CHO cells with IC50 of 32.4 nM.

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生物&药学活性

LY3358966 is a potent, selective inhibitor of the intestinal sodium‐dependent phosphate cotransporter NPT2b (NaPi-2b, SLC34A2), inhibits phosphate uptake in human NPT2b expressed in CHO cells with IC50 of 32.4 nM.
LY3358966 also inhibits mouse and rat NPT2b expressed in CHO cells with similar potencies (IC50=43.9 and 26.8 nM, respectively).
LY3358966 also inhibits human NPT2a (IC50=11 nM), displays 9-fold selectivity over human NPT2c (IC50=251 nM), and no acitivity against human PiT1 and PiT2 (IC50>100,000 nM).
LY3358966 inhibits phosphate absorption in mice, effectively reduces acute phosphate uptake into plasma.

物理化学性质&存储条件

分子量	801.951
分子式	C43H49F2N5O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2,6-difluoro-4-(2-(3-((4-((4-hydroxybutyl)carbamoyl)-2,2-dimethylpiperazin-1-yl)methyl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamido)phenethyl)benzoic acid

参考文献

1. Xiaojun Wang, et al. Pharmacol Res Perspect. 2022 Apr;10(2):e00938.

LY3358966 (LY 3358966)

生物&药学活性

物理化学性质&存储条件

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LY3358966 (LY 3358966)

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物理化学性质&存储条件

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