LY3214996 |CAS:1951483-29-6 Probechem Biochemicals

Chemical Structure : LY3214996

CAS No.: 1951483-29-6

加入收藏

LY3214996 (Temuterkib, LY-3214996)

货号: PC-61973Not For Human Use, Lab Use Only.

Temuterkib (LY-3214996) is a novel potent, selective, orally active ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays.

规格	价格	库存
2 mg	￥980	In stock
5 mg	￥1480	In stock
10 mg	￥2380	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Temuterkib (LY-3214996) is a novel potent, selective, orally active ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays.
Temuterkib (LY-3214996) potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.
Temuterkib (LY-3214996) demonstrates inhibition of cell proliferation, general sensitivitity against tumor cells with MAPK pathway alterations including BRAF, NRAS or KRAS mutation.
Temuterkib (LY-3214996) significantly inhibits tumor growth in vivo and is well tolerated in BRAF or NRAS mutant melanoma, BRAF or KRAS mutant colorectal, lung and pancreatic cancer xenografts or PDX models.

物理化学性质&存储条件

分子量	453.56
分子式	C22H27N7O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4H-Thieno[2,3-c]pyrrol-4-one,5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-

参考文献

1. Shripad V. Bhagwat, et al. AACR Abstract 4973.

LY3214996 (Temuterkib, LY-3214996)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LY3214996 (Temuterkib, LY-3214996)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.