LY3200882 | ALK5 inhibitor | Probechem Biochemicals

Chemical Structure : LY3200882

CAS No.: 1898283-02-7

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LY3200882 (LY-3200882)

货号: PC-63129Not For Human Use, Lab Use Only.

LY3200882 (LY-3200882) is a novel potent, highly selective, ATP competitive TGF-β receptor type 1 (TGFβRI, ALK5) inhibitor with IC50 of 38.2 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

LY3200882 (LY-3200882) is a novel potent, highly selective, ATP competitive TGF-β receptor type 1 (TGFβRI, ALK5) inhibitor with IC50 of 38.2 nM.
LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors.
LY3200882 shows potent anti-tumor activity in the orthotopic 4T1-LP model of triple negative breast cancer and this activity correlated with enhanced tumor infiltrating lymphocytes in the tumor microenvironment.

物理化学性质&存储条件

分子量	435.528
分子式	C24H29N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[[4-[[1-Cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]oxy]-2-pyridinyl]amino]-α,α-dimethyl-2-pyridinemethanol

参考文献

1. Huaxing Pei, et al. Abstract 955: LY3200882, a novel, highly selective TGFβRI small molecule inhibitor. AACR. DOI: 10.1158/1538-7445.

LY3200882 (LY-3200882)

生物&药学活性

物理化学性质&存储条件

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LY3200882 (LY-3200882)

生物&药学活性

物理化学性质&存储条件

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