欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-LY3154207
LY3154207

Chemical Structure : LY3154207

CAS No.: 1638667-79-4

加入收藏

LY3154207 (Mevidalen, LY-3154207)

货号: PC-73068Not For Human Use, Lab Use Only.

LY3154207 (Mevidalen, LY-3154207) is a potent, and subtype selective human dopamine D1 positive allosteric modulator (PAM) with EC50 of 3.0 nM.

规格 价格 库存 数量
1 mg ￥1880 In stock
5 mg ￥3680 In stock
10 mg ￥5580 In stock
25 mg ￥9880 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY3154207 (Mevidalen, LY-3154207) is a potent, and subtype selective human dopamine D1 positive allosteric modulator (PAM) with EC50 of 3.0 nM.
LY3154207 displays exquisite selectivity over the human D5 receptor subtype (EC50>10 uM), and 14 other GPCRs, including D2, β1, β2, and 5HT6 receptors.
Mevidalen enhanced wakefulness (latency to fall asleep) in the hD1 mouse in a dose dependent [3-100 mg/kg, orally (PO)] fashion.
Mevidalen promoted wakefulness in mice after prior sleep deprivation and delayed sleep onset by 5.5- and 15.2-fold compared with vehicle-treated animals.
Mevidalen demonstrated a dose-dependent increase in latency to sleep onset in human clinical investigations.

物理化学性质&存储条件

分子量 450.4
分子式 C24H29Cl2NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2,6-dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one

参考文献

1. Hao J, et al. J Med Chem. 2019 Oct 10;62(19):8711-8732.

2. McCarthy AP, et al. J Pharmacol Exp Ther. 2022 Mar;380(3):143-152.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: