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首页-小分子抑制剂&激动剂-GPCR-Free Fatty Acid Receptor (FFAR)-LY3104607
LY3104607

Chemical Structure : LY3104607

CAS No.: 1795232-22-2

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LY3104607 (LY-3104607;LY 3104607)

货号: PC-60235Not For Human Use, Lab Use Only.

LY3104607 (LY-3104607) is a potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LY3104607 (LY-3104607) is a potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM.
    LY3104607 demonstrates functional potency and glucose dependent insulin secretion in primary islets from rats.
    LY3104607 dose-dependently reduces glucose levels in vivo.

    物理化学性质&存储条件

    分子量 439.515
    分子式 C27H25N3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-3-(4-((2-(2,6-dimethylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)methoxy)phenyl)hex-4-ynoic acid

    参考文献

    1. Hamdouchi C, et al. J Med Chem. 2017 Dec 13. doi: 10.1021/acs.jmedchem.7b01411.

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