LY305 |CAS:1430230-83-3 Probechem Biochemicals

Chemical Structure : LY305

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LY305 (LY 305;LY-305)

货号: PC-35133Not For Human Use, Lab Use Only.

LY305 (LY-305) is a non-steroidal selective androgen receptor modulator (SARM) with Ki of 2.03 nM, demonstrates potent agonist activity in the aforementioned C2C12 cellular assay (EC50=0.499 nM).

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生物&药学活性

LY305 (LY-305) is a non-steroidal selective androgen receptor modulator (SARM) with Ki of 2.03 nM, demonstrates potent agonist activity in the aforementioned C2C12 cellular assay (EC50=0.499 nM).
LY305 displays little to no affinity for GR, PR and MR (Ki>800 nM).
LY305 shows the desired muscle and prostate effects in a preclinical ORX rat model.

物理化学性质&存储条件

分子量	264.753
分子式	C14H17ClN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-4-(((1R,2R)-2-hydroxy-2-methylcyclopentyl)amino)-3-methylbenzonitrile

参考文献

1. Krishnan V, et al. Andrology. 2018 Mar 12. doi: 10.1111/andr.12479.

2. Saeed A, et al. J Med Chem. 2016 Jan 28;59(2):750-5.

LY305 (LY 305;LY-305)

生物&药学活性

物理化学性质&存储条件

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LY305 (LY 305;LY-305)

生物&药学活性

物理化学性质&存储条件

参考文献

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