LY2940680 |CAS:1258861-20-9 Probechem Biochemicals

Chemical Structure : LY2940680

CAS No.: 1258861-20-9

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LY2940680 (LY 2940680;LY-2940680;Taladegib)

货号: PC-43422Not For Human Use, Lab Use Only.

LY2940680 (Taladegib) is potent Smoothened (SMO) receptor antagonist, potently inhibits Hedgehog (Hh) signaling with IC50 of 6.3 nM in Gli-luc reporter assyas.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

LY2940680 (Taladegib) is potent Smoothened (SMO) receptor antagonist, potently inhibits Hedgehog (Hh) signaling with IC50 of 6.3 nM in Gli-luc reporter assyas.
LY2940680 (Taladegib) inhibits medulloblastoma cell proliferation isolated from Ptch+/–p53–/– mice with IC50 of 43.5 nM.
LY2940680 (Taladegib) demonstrates anti-tumor activity in vivo with advanced basal cell carcinoma (BCC) and other malignancies.

物理化学性质&存储条件

分子量	512.502
分子式	C26H24F4N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 5.2 mg/mL
Chemical Name/SMILES	Benzamide, 4-fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)-

参考文献

1. Wang C, et al. Nature. 2013 May 16;497(7449):338-43.

2. Lauressergues E, et al. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214.

3. Jin G, et al. Arch Pharm Res. 2017 Dec;40(12):1390-1393.

4. Lu X, et al. Eur J Med Chem. 2017 Sep 29;138:384-395.

LY2940680 (LY 2940680;LY-2940680;Taladegib)

生物&药学活性

物理化学性质&存储条件

参考文献

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LY2940680 (LY 2940680;LY-2940680;Taladegib)

生物&药学活性

物理化学性质&存储条件

参考文献

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