LY2940094 | NOP receptor antagonist | Probechem Biochemicals

Chemical Structure : LY2940094

CAS No.: 1307245-86-8

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LY2940094 (LY-2940094, BTRX246040)

货号: PC-61546Not For Human Use, Lab Use Only.

LY2940094 (BTRX246040) is a potent, selective, CNS-penetrant, orally available NOP (Nociceptin/OFQ) receptor antagonist with Kb of 0.17 nM.

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5 mg	￥1480	In stock
10 mg	￥2280	In stock
25 mg	￥3780	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

LY2940094 (BTRX246040) is a potent, selective, CNS-penetrant, orally available NOP (Nociceptin/OFQ) receptor antagonist with Kb of 0.17 nM.
LY2940094 displays high selectivity versus classical opioid receptors (μ, δ, and κ).
LY2940094 inhibits fasting-induced feeding, inhibits feeding and body weight regain in dietary-induced obese mice.
LY2940094 also shows antidepressant-like effects in rodent models and antidepressant efficacy in patients with major depressive disorder (MDD).

物理化学性质&存储条件

分子量	480.959
分子式	C22H23ClF2N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[2-[4-[(2-Chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methyl-pyrazol-1-yl]-3-pyridyl]methanol

参考文献

1. Statnick MA, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):493-502.

2. Post A, et al. Neuropsychopharmacology. 2016 Jun;41(7):1803-12.

3. Toledo MA, et al. J Med Chem. 2014 Apr 24;57(8):3418-29.

4. Rorick-Kehn LM, et al. Alcohol Clin Exp Res. 2016 May;40(5):945-54.

LY2940094 (LY-2940094, BTRX246040)

生物&药学活性

物理化学性质&存储条件

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LY2940094 (LY-2940094, BTRX246040)

生物&药学活性

物理化学性质&存储条件

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