LY294002 |CAS:154447-36-6 Probechem Biochemicals

Chemical Structure : LY294002

CAS No.: 154447-36-6

加入收藏

LY294002 (NSC 697286;SF 1101;LY 294002;LY-294002)

货号: PC-42310Not For Human Use, Lab Use Only.

LY294002 is a classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively.

规格	价格	库存
50 mg	￥1280	In stock
100 mg	￥1880	In stock
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LY294002 is a classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively.
LY294002 completely and specifically abolishes PI3K activity (IC50=1.4 uM), but does not inhibit PI4K or other lipid kinases.
LY294002 demonstrates growth-inhibitory and apoptosis-inducing effect in colon cancer cell lines, with decreased phosphorylated Akt Ser(473).
LY294002 suppresses tumor growth in mouse xenografts.
LY294002 also is a potent inhibitor of CK2 with IC50 of 98 nM.

物理化学性质&存储条件

分子量	307.3432
分子式	C19H17NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 14.9 mg/mL
Chemical Name/SMILES	4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-

参考文献

1. Vlahos CJ, et al. J Biol Chem. 1994 Feb 18;269(7):5241-8.

2. Cheatham B, et al. Mol Cell Biol. 1994 Jul;14(7):4902-11.

3. Semba S, et al. Clin Cancer Res. 2002 Jun;8(6):1957-63.

4. Gharbi SI, et al. Biochem J. 2007 May 15;404(1):15-21.

LY294002 (NSC 697286;SF 1101;LY 294002;LY-294002)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LY294002 (NSC 697286;SF 1101;LY 294002;LY-294002)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.