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首页-小分子抑制剂&激动剂-GPCR-Free Fatty Acid Receptor (FFAR)-LY2922083
LY2922083

Chemical Structure : LY2922083

CAS No.: 1309435-78-6

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LY2922083 (LY 2922083;LY-2922083)

货号: PC-60238Not For Human Use, Lab Use Only.

LY2922083 is a potent, selective, orally available GPR40 agonist with EC50 of 9 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LY2922083 is a potent, selective, orally available GPR40 agonist with EC50 of 9 nM.
    LY2922083 displays no activity against PPARα/β/γ (>10 uM).
    LY2922083 demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo.

    物理化学性质&存储条件

    分子量 499.669
    分子式 C31H33NO3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-3-(4-((5-((2,3-dihydrospiro[indene-1,4'-piperidin]-1'-yl)methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid

    参考文献

    1. Hamdouchi C, et al. J Med Chem. 2016 Dec 22;59(24):10891-10916.

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