LY2857785 |CAS:1619903-54-6 Probechem Biochemicals

Chemical Structure : LY2857785

CAS No.: 1619903-54-6

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LY2857785 (LY 2857785;LY-2857785)

货号: PC-42956Not For Human Use, Lab Use Only.

LY2857785 is a potenrt, reversible and ATP-competitive CDK9 inhibitor with IC50 of 11 nM, also inhibits CDK8 (IC50=16 nM) and weakly inhibits CDK7 (IC50=246 nM).

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10 mg	￥2380	In stock
25 mg	￥3980	In stock
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生物&药学活性

LY2857785 is a potenrt, reversible and ATP-competitive CDK9 inhibitor with IC50 of 11 nM, also inhibits CDK8 (IC50=16 nM) and weakly inhibits CDK7 (IC50=246 nM).
LY2857785 showes good selectivity against a panel of 114 protein kinases.
LY2857785 inhibits RNAP II C-terminal domain (CTD) P-Ser2 and CTD P-Ser5 in U2OS cells with IC50 of 89 and 42 nM, dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines (MV-4-11 cell IC50=40 nM).
LY2857785 inhibits RNAP II CTD P-Ser2 in vivo, demonstrates potent antitumor growth efficacy in tumor xenografts.

物理化学性质&存储条件

分子量	448.6036
分子式	C26H36N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,4-Cyclohexanediamine, N1-[4-[2-methyl-3-(1-methylethyl)-2H-indazol-5-yl]-2-pyrimidinyl]-N4-(tetrahydro-2H-pyran-4-yl)-, trans-

参考文献

1. Yin T, et al. Mol Cancer Ther. 2014 Jun;13(6):1442-56.

LY2857785 (LY 2857785;LY-2857785)

生物&药学活性

物理化学性质&存储条件

参考文献

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LY2857785 (LY 2857785;LY-2857785)

生物&药学活性

物理化学性质&存储条件

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