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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Beta-secretase (BACE)-LY2811376
LY2811376

Chemical Structure : LY2811376

CAS No.: 1194044-20-6

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LY2811376 (LY 2811376, LY-2811376)

货号: PC-42607Not For Human Use, Lab Use Only.

LY2811376 is potent, orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM in enzyme assays.

规格 价格 库存 数量
5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥3280 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY2811376 is potent, orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM in enzyme assays.
LY2811376 demonstrates ∼10-fold selectivity over BACE2, and >50-fold over aspartyl proteases cathepsin D, pepsin, or renin.
LY2811376 produces profound Aβ-lowering effects in vivo.

物理化学性质&存储条件

分子量 320.3603
分子式 C15H14F2N4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

4H-1,3-Thiazin-2-amine, 4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-, (4S)-

参考文献

1. May PC, et al. J Neurosci. 2011 Nov 16;31(46):16507-16.

2. Filser S, et al. Biol Psychiatry. 2015 Apr 15;77(8):729-39.

3. Portelius E, et al. Alzheimers Res Ther. 2014 Nov 17;6(5-8):75.

4. Cheret C, et al. EMBO J. 2013 Jul 17;32(14):2015-28.

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