LY2780301 |CAS: 1226801-23-5 Probechem Biochemicals

Chemical Structure : LY2780301

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LY2780301 (LY-2780301, LY 2780301)

货号: PC-61416Not For Human Use, Lab Use Only.

LY2780301 is a potent, highly selective, ATP-competitive dual inhibitor of p70S6K and Akt under development for the treatment of solid tumours and non-Hodgkin's lymphoma.

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生物&药学活性

LY2780301 is a potent, highly selective, ATP-competitive dual inhibitor of p70S6K and Akt under development for the treatment of solid tumours and non-Hodgkin's lymphoma.
LY2780301 drastically decreases proliferation of hMECs with ErbB2-induced p70S6K activation via Cyclin B1 inhibition and cell cycle blockade at G0-G1 phase.
LY2780301 exhibited antiproliferative activity in a broad range of cell lines using monolayer and colony formation assays, reduces proliferation of hMECs in vitro and ADH/MIN lesions in vivo.

物理化学性质&存储条件

分子量	517.533
分子式	C25H27F4N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(1-(2-(dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

参考文献

1. Azaro A, et al. Invest New Drugs. 2015 Jun;33(3):710-9.

2. Wang X, et al. Cancer Prev Res (Phila). 2017 Sep 6. pii: canprevres.0106.2017.

3. Angevin E, et al. Eur J Cancer. 2017 Sep;83:194-202.

LY2780301 (LY-2780301, LY 2780301)

生物&药学活性

物理化学性质&存储条件

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LY2780301 (LY-2780301, LY 2780301)

生物&药学活性

物理化学性质&存储条件

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