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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Checkpoint Kinase (Chk)-LY2603618
LY2603618

Chemical Structure : LY2603618

CAS No.: 911222-45-2

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LY2603618 (IC-83;LY 2603618;LY-2603618;Rabusertib)

货号: PC-44037Not For Human Use, Lab Use Only.

Rabusertib (LY2603618) is a potent and selective small molecule inhibitor of Chk1 (IC50= 7 nM).

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5 mg ￥880 In stock
10 mg ￥1380 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Rabusertib (LY2603618) is a potent and selective small molecule inhibitor of Chk1 (IC50= 7 nM).
Rabusertib (LY2603618) promotes impaired DNA synthesis and elevates H2A.X phosphorylation indicative of DNA damage and premature entry into mitosis.

物理化学性质&存储条件

分子量 436.303
分子式 C18H22BrN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 29.5 mg/mL
Chemical Name/SMILES

Urea, N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)-

参考文献

1. King C, et al. Invest New Drugs. 2014 Apr;32(2):213-26.

2. Emiliano Calvo1, et al. Mol Cancer Ther, 2011, A94.

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