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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-LY2562175
LY2562175

Chemical Structure : LY2562175

CAS No.: 1103500-20-4

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LY2562175 (LY 2562175, TERN-101)

货号: PC-60079Not For Human Use, Lab Use Only.

LY2562175 (TERN-101) is a novel potent, selective, partial FXR agonist with EC50 of 193 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY2562175 (TERN-101) is a novel potent, selective, partial FXR agonist with EC50 of 193 nM.
LY-2562175 does not promote transcriptional activation of other nuclear receptor, such as GR, PR, MR and AR (EC50>10 uM).
LY-2562175 lowers LDL and triglycerides while raising HDL in preclinical species.

物理化学性质&存储条件

分子量 540.441
分子式 C28H27Cl2N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

100 mM in DMSO (54 mg/mL)
Chemical Name/SMILES

6-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid

参考文献

1. Genin MJ, et al. J Med Chem. 2015 Dec 24;58(24):9768-72.

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