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首页-小分子抑制剂&激动剂-GPCR-Leukotriene Receptor-LY255283
LY255283

Chemical Structure : LY255283

CAS No.: 117690-79-6

LY255283 (LY 255283)

货号: PC-21589Not For Human Use, Lab Use Only.

LY255283 is a selective, competitive antagonist of leukotriene B4 receptor (BLT2) with IC50 of 1 uM, 10-fold selective over BLT1 receptor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY255283 is a selective, competitive antagonist of leukotriene B4 receptor (BLT2) with IC50 of 1 uM, 10-fold selective over BLT1 receptor.
LY255283 inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2).
LY255283 reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration.

物理化学性质&存储条件

分子量 360.46
分子式 C19H28N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone

参考文献

1. D K Herron, et al. J Med Chem. 1992 May 15;35(10):1818-28.

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