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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Androgen Receptor (AR)-LY2452473
LY2452473

Chemical Structure : LY2452473

CAS No.: 1029692-15-6

LY2452473 (TT 701, OPK 88004, LY-2452473)

货号: PC-61999Not For Human Use, Lab Use Only.

LY2452473 (TT 701, OPK 88004) is an orally bioavailable selective androgen receptor modulator (SARM) being developed for the treatment of disorders related to hypogonadism.

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50 mg ¥2380 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY2452473 (TT 701, OPK 88004) is an orally bioavailable selective androgen receptor modulator (SARM) being developed for the treatment of disorders related to hypogonadism.
LY2452473 has the potential advantage of eliciting androgen receptor specificity and tissue selectivity to produce the beneficial effects of testosterone on bone, muscle, and improvements in erectile function over a PDE5i alone, with minimal steroid-related adverse effects.

物理化学性质&存储条件

分子量 374.444
分子式 C22H22N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Isopropyl N-[(2S)-7-cyano-4-(2-pyridylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate

参考文献

1. Yi P, et al. Drug Metab Dispos. 2012 Dec;40(12):2354-64.

2. Noey EL, et al. J Org Chem. 2017 Jun 2;82(11):5904-5909.

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