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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Glycine Transporter (GlyT)-LY2365109 hydrochloride
LY2365109 hydrochloride

Chemical Structure : LY2365109 hydrochloride

CAS No.: 1779796-27-8

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LY2365109 hydrochloride (LY-2365109 hydrochloride)

货号: PC-42145Not For Human Use, Lab Use Only.

LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor with IC50 of 15.8 nM, displays no activity for GlyT2 (IC50>30 uM).

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor with IC50 of 15.8 nM, displays no activity for GlyT2 (IC50>30 uM).
LY2365109 increases cerebrospinal fluid levels of glycine and potentiates NMDA-induced increases in dialysate levels of neurotransmitters in the prefrontal cortex (PFC) and the striatum.

物理化学性质&存储条件

分子量 421.9144
分子式 C22H28ClNO5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

Glycine, N-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methyl-,hydrochloride

参考文献

1. Perry KW, et al. Neuropharmacology. 2008 Oct;55(5):743-54.

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