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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Guanylate Cyclase-LY-83583
LY-83583

Chemical Structure : LY-83583

CAS No.: 91300-60-6

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LY-83583 (LY83583)

货号: PC-62156Not For Human Use, Lab Use Only.

LY-83583 (LY83583) is an inhibitor of soluble guanylate cyclase (sGC) and of cGMP production, inhibits sGC in human platelets with IC50 of 2 uM.

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY-83583 (LY83583) is an inhibitor of soluble guanylate cyclase (sGC) and of cGMP production, inhibits sGC in human platelets with IC50 of 2 uM.
LY-83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 uM.
LY-83583 is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with Ki of 3 uM.

物理化学性质&存储条件

分子量 250.3
分子式 C15H10N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(phenylamino)-5,8-quinolinedione

参考文献

1. Butcher RA, et al. Nat Chem Biol. 2006 Feb;2(2):103-9.

2. Mülsch A, et al. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):119-25.

3. Fleisch JH, et al. J Pharmacol Exp Ther. 1984 Jun;229(3):681-9.

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