LY-503430 |CAS:625820-83-9 Probechem Biochemicals

Chemical Structure : LY-503430

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LY-503430 (LY503430)

货号: PC-61722Not For Human Use, Lab Use Only.

LY-503430 is a novel AMPA receptor (AMPAR) potentiator that selectively enhances glutamate-induced calcium influx into HEK293 cells transfected with human GLUA1, GLUA2, GLUA3, or GLUA4 AMPA receptors with EC50 of 0.1-4 uM.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

LY-503430 is a novel AMPA receptor (AMPAR) potentiator that selectively enhances glutamate-induced calcium influx into HEK293 cells transfected with human GLUA1, GLUA2, GLUA3, or GLUA4 AMPA receptors with EC50 of 0.1-4 uM.
LY-503430 produces both nootropic and neuroprotective effects, reduces brain damage caused by 6-hydroxydopamine or MPTP and also increases levels of the neurotrophic factor BDNF in rat brain; orally active.

物理化学性质&存储条件

分子量	392.49
分子式	C20H25FN2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-{4-[(2R)-2-fluoro-1-(propane-2-sulfonamido)propan-2-yl]phenyl}-N-methylbenzamide

参考文献

1. Murray TK, et al. J Pharmacol Exp Ther. 2003 Aug;306(2):752-62.

2. O'Neill MJ, et al. CNS Drug Rev. 2005 Spring;11(1):77-96.

3. Ryder JW, et al. J Pharmacol Exp Ther. 2006 Oct;319(1):293-8.

LY-503430 (LY503430)

生物&药学活性

物理化学性质&存储条件

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LY-503430 (LY503430)

生物&药学活性

物理化学性质&存储条件

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