LY-404187 |CAS:211311-95-4 Probechem Biochemicals

Chemical Structure : LY-404187

CAS No.: 211311-95-4

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LY-404187 (LY404187)

货号: PC-61724Not For Human Use, Lab Use Only.

LY-404187 is a potent, selective, positive allosteric modulator of AMPA receptor (AMPAR) with EC50 of 1.3 uM.

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10 mg	￥1380	In stock
25 mg	￥2380	In stock
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生物&药学活性

LY-404187 is a potent, selective, positive allosteric modulator of AMPA receptor (AMPAR) with EC50 of 1.3 uM.
LY-404187 selectively enhances glutamate-evoked currents through AMPA receptor/channels of acutely isolated pyramidal neurons.
LY-404187 has been demonstrated to enhance cognitive function in animal studies, and has also shown effects suggesting antidepressant action as well as having possible application in the treatment of schizophrenia, Parkinson's disease and ADHD.

物理化学性质&存储条件

分子量	342.45
分子式	C19H22N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide

参考文献

1. Baumbarger PJ, et al. J Pharmacol Exp Ther. 2001 Jul;298(1):86-102.

2. Miu P, et al. Neuropharmacology. 2001 Jun;40(8):976-83.

3. O'Neill MJ, et al. Eur J Pharmacol. 2004 Feb 20;486(2):163-74.

LY-404187 (LY404187)

生物&药学活性

物理化学性质&存储条件

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LY-404187 (LY404187)

生物&药学活性

物理化学性质&存储条件

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