LY-3381916 | IDO1 inhibitor | Probechem Biochemicals

Chemical Structure : LY-3381916

CAS No.: 2166616-75-5

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LY-3381916 (LY3381916)

货号: PC-73168Not For Human Use, Lab Use Only.

LY-3381916 is a potent, selective and brain-penetrant Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with IC50 of 7 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

LY-3381916 is a potent, selective and brain-penetrant Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with IC50 of 7 nM.
LY-3381916 displays no significant inhibitory activity against TDO2 (IC50>20 uM), shows no confounding agonism of AHR up to 100 uM.
LY3381916 occupies the heme-binding pocket of IDO1, binds to newly synthesized apo-IDO1 lacking heme, but does not inhibit mature heme-bound IDO1.
LY-3381916 exhibits substantial inhibition of IDO1 in tumors requires the turn-over of mature heme-bound IDO1.
LY-3381916 enhances anti-PD-L1 antibody (LY3300054) activity in pre-clinical tumor model.

物理化学性质&存储条件

分子量	396.45
分子式	C23H25FN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-Fluoro-N-(1-(1-(tetrahydro-2H-pyran-4-carbonyl)indolin-5-yl)ethyl)benzamide

参考文献

1. Frank C. Dorsey, et al. Cancer Res (2018) 78 (13_Supplement): 5245.

LY-3381916 (LY3381916)

生物&药学活性

物理化学性质&存储条件

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LY-3381916 (LY3381916)

生物&药学活性

物理化学性质&存储条件

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