LY-2584702 hydrochloride | p70S6K1 inhibitor | Probechem Biochemicals

Chemical Structure : LY-2584702 hydrochloride

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LY-2584702 hydrochloride (LY2584702)

货号: PC-43060Not For Human Use, Lab Use Only.

LY2584702 is a potent, selective, ATP-competitive inhibitor of P70S6 kinase-1 (p70S6K1) with IC50 of 4 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

LY-2584702 hydrochloride is a potent, selective, ATP-competitive inhibitor of P70S6 kinase-1 (p70S6K1) with IC50 of 4 nM.
LY-2584702 blocks phosphorylation of p70S6K in primary rat hepatocytes without affecting the phosphorylation of other signaling kinases, including GSK-3β and ERK1/2.
LY-2584702 inhibits phosphorylation of p70S6K in HCT116 colon cancer cells with IC50 of 0.1-0.24 uM, demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.

物理化学性质&存储条件

分子量	481.877
分子式	C21H20ClF4N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-, hydrochloride (1:1)

参考文献

1. Estridge TB, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):108-118.

2. Tolcher A, et al. Eur J Cancer. 2014 Mar;50(5):867-75.

3. Hollebecque A, et al. Eur J Cancer. 2014 Mar;50(5):876-84.

LY-2584702 hydrochloride (LY2584702)

生物&药学活性

物理化学性质&存储条件

参考文献

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LY-2584702 hydrochloride (LY2584702)

生物&药学活性

物理化学性质&存储条件

参考文献

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