LXY18 | AURKB inhibitor | Probechem Biochemicals

Chemical Structure : LXY18

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LXY18 (LXY 18)

货号: PC-20713Not For Human Use, Lab Use Only.

LXY18 is a potent orally available blocker of AURKB relocation in mitosis with minimum effective concentration (MEC) of 3.5 nM for inducing polyploidy, shows broad-spectrum growth inhibitory and apoptosis-inducing activities with low nanomolar potencies.

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生物&药学活性

LXY18 is a potent orally available blocker of AURKB relocation in mitosis with minimum effective concentration (MEC) of 3.5 nM for inducing polyploidy, shows broad-spectrum growth inhibitory and apoptosis-inducing activities with low nanomolar potencies.
LXY18 potently inhibits 2C19 with an IC50 of 290 nM but has a negligible impact on the other CYP450s, indicating a low risk of drug-drug interaction.
LXY18 prevents cytokinesis by blocking AURKB relocalization in mitosis and exhibits broad-spectrum antimitotic activity in vitro.
LXY18 shows widespread tissue distribution including the blood-brain barrier penetrance and effective accumulation in tumor tissues.
LXY18 markedly suppresses tumor growth in vivo.

物理化学性质&存储条件

分子量	387.23
分子式	C18H15BrN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((6-bromoquinolin-4-yl)oxy)-5-methoxyphenyl)acetamide

参考文献

1. Li J, et al. J Pharm Biomed Anal. 2023 Apr 24;232:115415.

2. J. Li, et al. BioRxiv, 2023 (2023), 10.1101/2023.01.29.526078

LXY18 (LXY 18)

生物&药学活性

物理化学性质&存储条件

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LXY18 (LXY 18)

生物&药学活性

物理化学性质&存储条件

参考文献

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