LXRβ agonist 17 |CAS:1878259-00-7 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Liver X Receptor (LXR)-LXRβ agonist 17

Chemical Structure : LXRβ agonist 17

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LXRβ agonist 17

货号: PC-61598Not For Human Use, Lab Use Only.

LXRβ agonist 17 is a potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LXRβ agonist 17 is a potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα.
LXRβ agonist 17 also exhibits excellent selectivity against other nuclear hormone receptors (>3,000-fold).
LXRβ agonist 17 induces the expression of LXR target genes in vitro and in vivo.

物理化学性质&存储条件

分子量	488.526
分子式	C21H27F3N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-(2-(4-(4-(Hydroxymethyl)-3-(methylsulfonyl)phenyl)-2-isopropylpiperazin-1-yl)-4-(trifluoromethyl)pyrimidin-5-yl)methanol

参考文献

1. Zheng Y, et al. J Med Chem. 2016 Apr 14;59(7):3264-71.

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LXRβ agonist 17

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LXRβ agonist 17

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物理化学性质&存储条件

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