LXR-623 |CAS:875787-07-8 Probechem Biochemicals

Chemical Structure : LXR-623

CAS No.: 875787-07-8

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LXR-623 (WAY-252623;LXR623;LXR 623;WAY252623;WAY 252623)

货号: PC-42687Not For Human Use, Lab Use Only.

LXR-623 (WAY 252623) is a clinically viable, highly brain-penetrant LXRα-partial/LXRβ-full agonist with binding Ki of 33 nM/248 nM, respectively.

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25 mg	￥1980	In stock
100 mg	￥4880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

LXR-623 (WAY 252623) is a clinically viable, highly brain-penetrant LXRα-partial/LXRβ-full agonist with binding Ki of 33 nM/248 nM, respectively.
LXR-623 selectively kills GBM cells in an LXRβ- and cholesterol-dependent fashion, causing tumor regression and prolonged survival in mouse models.

物理化学性质&存储条件

分子量	422.7784
分子式	C21H12ClF5N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 47 mg/mL
Chemical Name/SMILES	2H-Indazole, 2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-

参考文献

1. Wrobel J, et al. J Med Chem. 2008 Nov 27;51(22):7161-8.

2. DiBlasio-Smith EA, et al. J Transl Med. 2008 Oct 16;6:59.

3. Villa GR, et al. Cancer Cell. 2016 Nov 14;30(5):683-693.

LXR-623 (WAY-252623;LXR623;LXR 623;WAY252623;WAY 252623)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

LXR-623 (WAY-252623;LXR623;LXR 623;WAY252623;WAY 252623)

生物&药学活性

物理化学性质&存储条件

参考文献

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