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首页-小分子抑制剂&激动剂-Others-Other Targets-LXG6403
LXG6403

Chemical Structure : LXG6403

CAS No.: 315705-04-5

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LXG6403 (LXG-6403)

货号: PC-22844Not For Human Use, Lab Use Only.

LXG6403 is a highly potent, irreversible lysyl oxidase (LOX) inhibitor, inhibits cellular LOX activity efficiently in MDA-MB-231 cells with IC50 of 1.3 uM, >3-fold selective over LOXL2 and no activity against LOXL1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LXG6403 is a highly potent, irreversible lysyl oxidase (LOX) inhibitor, inhibits cellular LOX activity efficiently in MDA-MB-231 cells with IC50 of 1.3 uM, >3-fold selective over LOXL2 and no activity against LOXL1.
LXG6403 inhibits cellular LOX activity with IC50 values of 1.3 μM, 1.43 μM, 4.14 μM, and 3.0 μM in MDA-MB-231, HCC143, Hs-578-T, and HCC1937 cells.
LXG6403 enhances chemoresponse in 3D cultures of TNBC cell lines and PDX organoids.
LXG6403 diminishes collagen crosslinking/deposition and increases drug penetration in 3D culture, inhibiting FAK signaling and potentiating ROS/DNA damage axis.
LXG6403 rewires collagen architecture/signaling, overcomes doxorubicin resistance in chemoresistant TNBC PDXs in vivo.

物理化学性质&存储条件

分子量 345.44
分子式 C15H15N5OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[4-[[4-(2-amino-4-methyl-thiazol-5-yl)thiazol-2-yl]amino]phenyl]acetamide

参考文献

1. Cetin M, et al. Cell Chem Biol. 2024 Jul 9:S2451-9456(24)00273-3.

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