LX2761 | SGLT1/2 inhibitor | Probechem Biochemicals

Chemical Structure : LX2761

加入收藏

LX2761 (LX 2761, LX-2761)

货号: PC-60689Not For Human Use, Lab Use Only.

LX2761 is a potent, locally acting and orally bioavailable SGLT1 inhibitor that inhibits human SGLT1- and SGLT2-mediated glucose uptake with IC50 of 2.2 nM and 2.7 nM, respectively, restricted to the intestinal lumen.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LX2761 is a potent, locally acting and orally bioavailable SGLT1 inhibitor that inhibits human SGLT1- and SGLT2-mediated glucose uptake with IC50 of 2.2 nM and 2.7 nM, respectively, restricted to the intestinal lumen.
LX2761 synergistically increases active GLP-1 levels combined with sitagliptin, lowers postprandial glucose, fasting glucose, and hemoglobin A1C, and increased plasma total GLP-1 in mice.
LX2761 delays intestinal glucose absorption in vivo to improve glycemic control.

物理化学性质&存储条件

分子量	601.803
分子式	C32H47N3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-((2-(Dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-butanamide

参考文献

1. Goodwin NC, et al. J Med Chem. 2017 Jan 26;60(2):710-721.

2. Powell DR, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):85-97.

LX2761 (LX 2761, LX-2761)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LX2761 (LX 2761, LX-2761)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.