LX-2343 |CAS:333745-53-2 Probechem Biochemicals

Chemical Structure : LX-2343

CAS No.: 333745-53-2

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LX-2343 (LX2343)

货号: PC-63276Not For Human Use, Lab Use Only.

LX-2343 (LX2343) is an non-ATP competitive PI3K inhibitor that negatively regulates AKT/mTOR signaling, thus promoting autophagy and increasing Aβ clearance, also inhibits BACE1 enzymatic activity with IC50 of 11.43 uM.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

LX-2343 (LX2343) is an non-ATP competitive PI3K inhibitor that negatively regulates AKT/mTOR signaling, thus promoting autophagy and increasing Aβ clearance, also inhibits BACE1 enzymatic activity with IC50 of 11.43 uM.
LX-2343 reduced Aβ production involving JNK/APPThr668 pathway inhibition.
LX-2343 LX2343 (5-20 uM) dose-dependently decreases Aβ accumulation in HEK293-APPsw and CHO-APP cells, and promotes Aβ clearance in SH-SY5Y cells and primary astrocytes.
LX-2343 significantly ameliorates cognitive deficits and markedly ameliorates the Aβ pathology in brains in APP/PS1 transgenic mice.

物理化学性质&存储条件

分子量	474.912
分子式	C22H19ClN2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide

参考文献

1. Guo XD, et al. Acta Pharmacol Sin. 2016 Sep;37(10):1281-1297.

2. Guo XD, et al. Acta Pharmacol Sin. 2017 Aug;38(8):1104-1119.

3. Sun G, et al. Eur J Med Chem. 2018 Feb 10;145:622-633.

LX-2343 (LX2343)

生物&药学活性

物理化学性质&存储条件

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LX-2343 (LX2343)

生物&药学活性

物理化学性质&存储条件

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