LW1646 | PDE5 inhibitor | Probechem Biochemicals

Chemical Structure : LW1646

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LW1646 (LW-1646)

货号: PC-27748Not For Human Use, Lab Use Only.

LW1646 is a potent, selective and orally available PDE5 inhibitor with IC50 of 1.09 nM, exerts antifibrotic effects.

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生物&药学活性

LW1646 is a potent, selective and orally available PDE5 inhibitor with IC50 of 1.09 nM, exerts antifibrotic effects.
LW1646 alleviated ER stress and pro-fibrotic responses in HK-2 cells via activating cGMP signaling.
LW1646 showed a stronger ability than sildenafil to promote VASP Ser239 phosphorylation.
LW1646 markedly decreased the expression of these fibrosis-associated proteins.
LW1646 preserved mitochondrial biogenesis and membrane potential.
LW1646 improved mitochondrial dynamics disturbance and oxidative stress induced by TGF-β1 in HK-2 cells.
LW1646 relieved 7UUO-induced renal fibrosis in mice via inhibiting ER stress and maintaining mitochondrial homeostasis.
LW1646 alleviated mitochondrial Ca2+ overload induced by ER stress under pro-fibrotic conditions.

物理化学性质&存储条件

分子量	416.45
分子式	C23H16N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(benzo[d][1,3]dioxol-5-ylmethyl)-7-methyl-1-(thiazol-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one

参考文献

1. Wang M, et al. Free Radic Biol Med. 2026 Aug 19:S0891-5849(26)01040-3.

2. Patent CN109134481 A 2019-01-04.

LW1646 (LW-1646)

生物&药学活性

物理化学性质&存储条件

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LW1646 (LW-1646)

生物&药学活性

物理化学性质&存储条件

参考文献

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