LW106 | IDO1 inhibitor | Probechem Biochemicals

Chemical Structure : LW106

加入收藏

LW106 (LW-106)

货号: PC-22837Not For Human Use, Lab Use Only.

LW106 is a selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor with IC50 of 1.57 uM in IFN‐γ‐stimulated HeLa cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LW106 is a selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor with IC50 of 1.57 uM in IFN‐γ‐stimulated HeLa cells.
LW106 inhibited tumour outgrowth via blocking activity of IDO1 expressed by the host‐derived cells but not the inoculated tumour cells.
LW106 dose‐dependently inhibited outgrowth of IDO1‐nonexpressing tumour cells inoculated in C57BL6 mice but not athymic nude mice or Ido1 −/− mice.
LW106 treatment enhances the infiltration and accumulation of T cells in xenografted tumours.
LW106 treatment results in impaired proliferation and survival of Lewis tumour cells in tandem with reduced recruitment of tumour‐associated stromal cells and accumulation of extracellular matrix.
LW106 treatment inhibits cancer stem cell enrichment in Lewis tumours.

物理化学性质&存储条件

分子量	245.24
分子式	C11H11N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-Amino-1,2,5-oxadiazol-3-yl)(1,3-dihydro-2H-isoindol-2-yl)methanone oxime

参考文献

1. Rong Fu, et al. Br J Pharmacol. 2018 Jul;175(14):3034-3049.

LW106 (LW-106)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LW106 (LW-106)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.