LUF7346 |CAS:1821638-40-7 Probechem Biochemicals

Chemical Structure : LUF7346

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LUF7346 (LUF-7346;LUF 7346)

货号: PC-63511Not For Human Use, Lab Use Only.

LUF7346 is a novel hERG allosteric modulator that slows IKr deactivation and positively shifting IKr inactivation.

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生物&药学活性

LUF7346 is a novel hERG allosteric modulator that slows IKr deactivation and positively shifting IKr inactivation.
LUF7346 rescues the genetic form of LQTS, reverses drug-induced LQTS and correct thes combination of genetic and drug-induced LQTS.
LUF7346 normalises both action- and field potentials (AP and FP, respectively) in all hPSC-CMs by slowing IKr deactivation and positively shifting the IKr inactivation.

物理化学性质&存储条件

分子量	411.255
分子式	C20H15BrN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(2-bromobenzoyl)phenoxy)-N-(pyridin-3-yl)acetamide

参考文献

1. Sala L, et al. EMBO Mol Med. 2016 Sep 1;8(9):1065-81.

2. Yu Z, et al. Eur J Med Chem. 2015 Dec 1;106:50-9.

3. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439.

LUF7346 (LUF-7346;LUF 7346)

生物&药学活性

物理化学性质&存储条件

参考文献

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LUF7346 (LUF-7346;LUF 7346)

生物&药学活性

物理化学性质&存储条件

参考文献

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