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首页-小分子抑制剂&激动剂-Apoptosis-Receptor Interacting Protein Kinase (RIPK)-LT-1339-553
LT-1339-553

Chemical Structure : LT-1339-553

CAS No.: 3078683-57-2

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LT-1339-553

货号: PC-26869Not For Human Use, Lab Use Only.

LT-1339-553 is a potent, selective and oral bioavailable RIPK1 inhibitor with IC50 of 4.32 nM, cellular antinecroptotic activity (EC50=14.43 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LT-1339-553 is a potent, selective and oral bioavailable RIPK1 inhibitor with IC50 of 4.32 nM, cellular antinecroptotic activity (EC50=14.43 nM).
LT-1339-553 significantly alleviates liver injury, inflammation, and collagen deposition in murine model of hepatic fibrosis.
LT-1339-553 suppresses the AKT/PI3K/NF-κB and IL-17 pathways.

物理化学性质&存储条件

分子量 464.35
分子式 C21H13F5N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-(3-aminobenzo[d]isoxazol-4-yl)-2,3-difluorophenyl)-3-(3-(trifluoromethoxy)phenyl)urea

参考文献

1. Lu JL, et al. J Med Chem. 2026 May 16. doi: 10.1021/acs.jmedchem.5c03775.

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