LSZ102 |CAS:2135600-76-7 Probechem Biochemicals

Chemical Structure : LSZ102

CAS No.: 2135600-76-7

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LSZ102 (LSZ 102;LSZ-102)

货号: PC-63293Not For Human Use, Lab Use Only.

LSZ102 is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) with ERα transcription IC50 of 6 nM and ERα degradation IC50 of 0.2 nM.

规格	价格	库存
5 mg	￥2280	In stock
25 mg	￥5280	In stock
100 mg	￥12800	In stock
500 mg		Get quote
1 g		Get quote

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生物&药学活性

LSZ102 is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) with ERα transcription IC50 of 6 nM and ERα degradation IC50 of 0.2 nM.
LSZ102 robustly causes inhibition of cell proliferation in MCF-7 cells with IC50 of 1.7 nM, inhibits the mRNA level of canonical endogenous ER target gene GREB1 with IC50 of 8.9 nM.
LSZ102 demonstrates anti-tumor efficacy in the ER+ human breast cancer MCF-7 xenograft model (10 mg/kg).

物理化学性质&存储条件

分子量	470.462
分子式	C25H17F3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(4-((2-(2-(1,1-Difluoroethyl)-4-fluorophenyl)-6-hydroxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

参考文献

1. Tria GS, et al. J Med Chem. 2018 Apr 12;61(7):2837-2864.

LSZ102 (LSZ 102;LSZ-102)

生物&药学活性

物理化学性质&存储条件

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LSZ102 (LSZ 102;LSZ-102)

生物&药学活性

物理化学性质&存储条件

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