LSP4-2022 |CAS:1413405-33-0 Probechem Biochemicals

Chemical Structure : LSP4-2022

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LSP4-2022

货号: PC-62983Not For Human Use, Lab Use Only.

LSP4-2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays.

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生物&药学活性

LSP4-2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays.
LSP4-2022 displays >100-fold selectivity over mGlu7 and mGlu8 (IC50=11.6 and 29.2 uM), no activity at the group I and -II mGlu receptors (EC50>100 uM).
LSP4-2022 inhibits neurotransmission in cerebellar slices from mice, and possesses antiparkinsonian properties in a haloperidol-induced catalepsy test.

物理化学性质&存储条件

分子量	347.26
分子式	C13H18NO8P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-amino-4-({[4-(carboxymethoxy)phenyl](hydroxy)methyl}(hydroxy)phosphoryl)butanoic acid

参考文献

1. Goudet C, et al. FASEB J. 2012 Apr;26(4):1682-93.

2. Vilar B, et al. J Neurosci. 2013 Nov 27;33(48):18951-65.

3. Podkowa K, et al. Neuropharmacology. 2015 Oct;97:338-45.

LSP4-2022

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物理化学性质&存储条件

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LSP4-2022

生物&药学活性

物理化学性质&存储条件

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