LSP1-2111 | group III mGluR agonist | Probechem Biochemicals

Chemical Structure : LSP1-2111

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LSP1-2111 (group III mGluR agonist)

货号: PC-62982Not For Human Use, Lab Use Only.

LSP1-2111 is a potent, selective, and brain penetrant group III mGluRs agonist with EC50 of 2.2 and 1.7 uM for mGluR4 and mGluR6, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

LSP1-2111 is a potent, selective, and brain penetrant group III mGluRs agonist with EC50 of 2.2 and 1.7 uM for mGluR4 and mGluR6, respectively.
LSP1-2111 displays 25-, and 30-fold preference over mGlu7 and mGlu8 receptors.
LSP1-2111 selectively inhibits striatopallidal GABAergic transmission with no effect at a synapse modulated solely by the mGlu7 and mGlu8 receptors.
LSP1-2111 counteracts haloperidol-induced catalepsy in experimental parkinson model.

物理化学性质&存储条件

分子量	364.247
分子式	C12H17N2O9P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-amino-4-{hydroxy[hydroxy(4-hydroxy-3-methoxy-5-nitrophenyl)methyl]phosphoryl}butanoic acid

参考文献

1. Cajina M, et al. ACS Med Chem Lett. 2013 Dec 12;5(2):119-23.

2. Wierońska JM, et al. Neuropharmacology. 2010 Dec;59(7-8):627-34.

3. Wierońska JM, et al. Psychopharmacology (Berl). 2013 Jun;227(4):711-25.

4. Beurrier C, et al. FASEB J. 2009 Oct;23(10):3619-28.