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首页-小分子抑制剂&激动剂-Others-Other Targets-LSN3441732
LSN3441732

Chemical Structure : LSN3441732

CAS No.: 2963629-69-6

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LSN3441732 (LSN-3441732)

货号: PC-24908Not For Human Use, Lab Use Only.

LSN3441732 is a potent, dimeric apolipoprotein(a) (apo(a)) binder and inhibitor of Lipoprotein(a) (Lp(a)) formation, disrupts the formation of Lp(a) with IC50 of 0.18 nM in in vitro Lp(a) assembly assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LSN3441732 is a potent, dimeric apolipoprotein(a) (apo(a)) binder and inhibitor of Lipoprotein(a) (Lp(a)) formation, disrupts the formation of Lp(a) with IC50 of 0.18 nM in in vitro Lp(a) assembly assays.
3H-LSN3441732 binds to full-length apo(a) with Kd of 0.05  nM, with Bmax = 4.9 fmol ng−1 apo(a).
3H-LSN3441732 has high affinity for single KIV7 (Kd = 2.8 nM) and KIV8 (Kd = 2.0 nM).
LSN3441732 shows improvements in potency and efficacy both in vitro and in vivo compared with the monovalent inhibitor.

物理化学性质&存储条件

分子量 567.51
分子式 C27H36Cl2N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,2'S)-3,3'-((carbonylbis(azanediyl))bis(3,1-phenylene))bis(2-((R)-pyrrolidin-3-yl)propanoic acid) dihydrochloride

参考文献

1. Nuria Diaz, et al. Nature. 2024 May;629(8013):945-950.

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