LSN 3213128 |CAS:1941211-99-9 Probechem Biochemicals

Chemical Structure : LSN 3213128

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LSN 3213128 (LSN3213128)

货号: PC-62007Not For Human Use, Lab Use Only.

LSN 3213128 is a novel potent, selective and orally-bioavailable antifolate with potent and specific inhibitory activity for AICARFT.

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生物&药学活性

LSN 3213128 is a novel potent, selective and orally-bioavailable antifolate with potent and specific inhibitory activity for AICARFT.
LSN 3213128 treatment results in dramatic elevation of 5-aminoimidazole 4-carboxamide ribonucleotide (ZMP) and growth inhibition in NCI-H460 and MDA-MB-231met2 cancer cell lines.
LSN 3213128 demonstrates tumor growth inhibition in a murine based xenograft model of triple negative breast cancer (TNBC).
Aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) is an enzyme in the purine biosynthetic pathway.

物理化学性质&存储条件

分子量	409.45
分子式	C17H16FN3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide

参考文献

1. Fales KR, et al. J Med Chem. 2017 Oct 26. doi: 10.1021/acs.jmedchem.7b01046.

LSN 3213128 (LSN3213128)

生物&药学活性

物理化学性质&存储条件

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LSN 3213128 (LSN3213128)

生物&药学活性

物理化学性质&存储条件

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