LSD1 inhibitor-1 |CAS:927019-63-4 Probechem Biochemicals

Chemical Structure : LSD1 inhibitor-1

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LSD1 inhibitor-1

货号: PC-61644Not For Human Use, Lab Use Only.

LSD1 inhibitor-1 is a bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 uM in vitro.

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生物&药学活性

LSD1 inhibitor-1 is a bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 uM in vitro.
LSD1 inhibitor-1 significantly increases H3K4me1 and H3K4me2 dose-dependently from 0.25 uM to 10 uM, without affecting global H3K9me2 in HCT116 human colon carcinoma cells.
LSD1 inhibitor-1 induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.

物理化学性质&存储条件

分子量	328.5
分子式	C15H36N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N'-dimethyl-15-(methylimino)-2,6,10,14,16-pentaazaheptadecanimidamide

参考文献

1. Sharma SK, et al. J Med Chem. 2010 Jul 22;53(14):5197-212.

2. Huang Y, et al. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8023-8.

3. Bi X, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3229-32.

LSD1 inhibitor-1

生物&药学活性

物理化学性质&存储条件

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LSD1 inhibitor-1

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物理化学性质&存储条件

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