LRPPRC inhibitor 3o | LRPPRC inhibitor | Probechem Biochemicals

Chemical Structure : LRPPRC inhibitor 3o

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LRPPRC inhibitor 3o (LRPPRC-IN-1)

货号: PC-27294Not For Human Use, Lab Use Only.

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生物&药学活性

LRPPRC inhibitor 3o (LRPPRC-IN-1) is a potent small molecule inhibitor of Leucine-rich pentatricopeptide repeat containing (LRPPRC) with IC50 of <5 uM (92% inhibition at 6.25 uM), induces robust LRPPRC degradation.
LRPPRC inhibitor 3o downregulates downstream OXPHOS subunits and ATP synthase, elicits broad antiproliferative effects in refractory and drug-resistant A549, BXPC-3, and NCI-H1975 cells (IC50=0.27-1.39 uM).
LRPPRC inhibitor 3o achieved tumor growth inhibition (TGI) rates of 73 and 49% with favorable safety profiles in PC9 and HCT116 xenografts.

物理化学性质&存储条件

分子量	574.15
分子式	C21H13Br2F3N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N'-(3,5-dibromo-2,4-dihydroxybenzylidene)-3-hydroxy-2'-(trifluoromethyl)-[1,1'-biphenyl]-4-carbohydrazide

参考文献

1. Ren H, et al. J Med Chem. 2026 Jul 13. doi: 10.1021/acs.jmedchem.6c00936.

LRPPRC inhibitor 3o (LRPPRC-IN-1)

生物&药学活性

物理化学性质&存储条件

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LRPPRC inhibitor 3o (LRPPRC-IN-1)

生物&药学活性

物理化学性质&存储条件

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