LQFM215 | SLC6A7 inhibitor | Probechem Biochemicals

Chemical Structure : LQFM215

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LQFM215 (LQFM-215)

货号: PC-21191Not For Human Use, Lab Use Only.

LQFM215 (LQFM-215) is a synthetic L-proline transporter (PROT/SLC6A7) inhibitor, inhibits proline uptake in hippocampal synaptosome with IC50 of 20.4 uM, present neuroprotective potential.

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生物&药学活性

LQFM215 (LQFM-215) is a synthetic L-proline transporter (PROT/SLC6A7) inhibitor, inhibits proline uptake in hippocampal synaptosome with IC50 of 20.4 uM, present neuroprotective potential.
LQFM215 (10.0 mg/kg) reduces animal motility, without inducing anxious, depressive behaviors, or cognitive impairments, evaluated in the open-field test in mice.
LQFM215 (10.0 mg/kg) prevents an increase in infarction area and motor impairments in the MCAO model, reduces infarction area and motor impairments in the MCAO model.

物理化学性质&存储条件

分子量	394.56
分子式	C25H34N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3,5-di-tert-butyl-4-hydroxyphenyl)(4-phenylpiperazin-1-yl)methanone

参考文献

1. Carvalho GA, et al. Pharmacol Rep. 2023 Apr;75(2):276-292.

2. Carvalho GA, et al. Neurochem Res. 2023 Sep 9. doi: 10.1007/s11064-023-04018-3.

LQFM215 (LQFM-215)

生物&药学活性

物理化学性质&存储条件

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LQFM215 (LQFM-215)

生物&药学活性

物理化学性质&存储条件

参考文献

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