LQB-118 |CAS:1219104-20-7 Probechem Biochemicals

Chemical Structure : LQB-118

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LQB-118 (LQB 118, LQB118)

货号: PC-60560Not For Human Use, Lab Use Only.

LQB-118 is an orally active pterocarpanquinone that exhibits antitumoral and antileishmanial activity both in vitro and in vivo.

规格	价格	库存	数量
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100 mg		Get quote

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生物&药学活性

LQB-118 is an orally active pterocarpanquinone that exhibits antitumoral and antileishmanial activity both in vitro and in vivo.
LQB-118 induces apoptosis in cells derived from chronic myeloid leukemia patients, exhibiting multifactorial drug resistance phenotype such as P-glycoprotein, MRP1 and p53 overexpression.
LQB-118 shows activity active against intracellular amastigotes of L. amazonensis with IC50 of 1.4 uM, inhibits parasite growth in L.amazonensis-infected BALB/c mice.

物理化学性质&存储条件

分子量	304.3
分子式	C19H12O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7aS,12aS)-7,7a-dihydro-5H-benzo[g]benzofuro[3,2-c]chromene-5,13(12aH)-dione

参考文献

1. Maia RC, et al. Invest New Drugs. 2011 Dec;29(6):1143-55.

2. de Souza Reis FR, et al. Anticancer Agents Med Chem. 2013 Feb;13(2):341-51.

3. Martino T, et al. Bioorg Med Chem. 2014 Jun 15;22(12):3115-22.

4. Martino T, et al. Prostate. 2018 Feb;78(2):140-151.

LQB-118 (LQB 118, LQB118)

生物&药学活性

物理化学性质&存储条件

参考文献

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LQB-118 (LQB 118, LQB118)

生物&药学活性

物理化学性质&存储条件

参考文献

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