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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-LPC-058
LPC-058

Chemical Structure : LPC-058

CAS No.: 1363368-18-6

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LPC-058 (LPC058)

货号: PC-25324Not For Human Use, Lab Use Only.

LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), displays broad-spectrum antibiotic activity against antibiotic resistant Gram-negative pathogens.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), displays broad-spectrum antibiotic activity against antibiotic resistant Gram-negative pathogens.
LPC-058 has MIC90 values for Enterobacteriaceae, P. aeruginosa, Burkholderia cepacia and A. baumannii of 0.12, 0.5, 1 and 1 mg/L, respectively.
LPC-058 is bactericidal at 1× or 2× MIC against CTX-M-15, KPC-2 and VIM-1 carbapenemase-producing strains and bacteriostatic at ≤4× MIC against OXA-23 carbapenemase-producing A. baumannii.
Combinations of LPC-058 with β-lactams, amikacin and ciprofloxacin are synergistic against these strains, albeit in a species-dependent manner.

物理化学性质&存储条件

分子量 427.41
分子式 C22H19F2N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[(4-Aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide

参考文献

1. Titecat M, et al. J Antimicrob Chemother. 2016 Oct;71(10):2874-82.

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