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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-LP99
LP99

Chemical Structure : LP99

CAS No.: 1808951-93-0

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LP99 (BRD7/9 inhibitor LP99)

货号: PC-62299Not For Human Use, Lab Use Only.

LP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99 nM for BRD9.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99 nM for BRD9.
LP99 inhibits IL‐6 secretion from THP‐1 cells in a dose‐dependent manner.
LP99 decreases BRET for both BRD7 and BRD9 in both the H3.3 and H4 systems in a dose‐dependent manner, with cellular IC50 values in the low micromolar range for both histones.

物理化学性质&存储条件

分子量 516.05
分子式 C26H30ClN3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide

参考文献

1. Clark PG, et al. Angew Chem Weinheim Bergstr Ger. 2015 May 18;127(21):6315-6319.

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