LP-403812 | Proline transporter inhibitor | Probechem Biochemicals

Chemical Structure : LP-403812

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LP-403812 (LP403812)

货号: PC-21227Not For Human Use, Lab Use Only.

LP-403812 is a specific small molecule inhibitor of mammalian proline transporter (PROT), inhibits PROT-mediated proline uptake with IC50 of 0.1 uM on both recombinant human and mouse PROT.

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生物&药学活性

LP-403812 is a specific small molecule inhibitor of mammalian proline transporter (PROT), inhibits PROT-mediated proline uptake with IC50 of 0.1 uM on both recombinant human and mouse PROT.
LP-403812 shows no significant inhibition of glycine and dopamine transporters at concentrations up to 10 uM.
LP-403812 inhibits proline transporter activity of mouse brain synaptosomes with the same potency.

物理化学性质&存储条件

分子量	494.66
分子式	C26H34N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[1-(1,1-dimethylethyl)-3-[[(2S)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrazolo[3,4-d]thiazol-5-yl]-4-methyl-

参考文献

1. Xuan-Chuan Yu, et al. Neurosci Lett. 2009 Feb 27;451(3):212-6.

LP-403812 (LP403812)

生物&药学活性

物理化学性质&存储条件

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LP-403812 (LP403812)

生物&药学活性

物理化学性质&存储条件

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