LP-211 | 5-HT7 agonist | Probechem Biochemicals

Chemical Structure : LP-211

CAS No.: 1052147-86-0

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LP-211 (LP211)

货号: PC-73300Not For Human Use, Lab Use Only.

LP-211 is a potent, selective, and BBB-penetrant 5-HT7 receptor agonist with Ki of 0.58 nM, high selectivity over 5-HT1A receptor (Ki, 188 nM) and D2 receptor (Ki, 142 nM).

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

LP-211 is a potent, selective, and brain penetrant 5-HT7 receptor agonist with Ki of 0.58 nM, high selectivity over 5-HT1A receptor (Ki, 188 nM) and D2 receptor (Ki, 142 nM).
LP-211 displays excellent selectivity profile over a panel of 5-HT receptor subtypes.|
LP-211 (0.25 and 0.50 mg/kg i.p.) improves consolidation of chamber-shape memory in rats, resulting in significant novelty-induced hyperactivity and recognition.
LP-211 (0.003-0.3 mg/kg, i.p.) significantly increases the micturition volume in a dose-dependent manner, and causes significant increases in voiding efficiency in spinal cord-injured (SCI) rats, and such effects can be completely reversed by 5-HT7 antagonist SB-269970.

物理化学性质&存储条件

分子量	466.629
分子式	C30H34N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide

参考文献

1. Hedlund PB, et al. Neurosci Lett. 2010 Aug 30;481(1):12-6.

2. Leopoldo M, et al. J Med Chem. 2008 Sep 25;51(18):5813-22.

3. Speranza L, et al. Neuropharmacology. 2013 Apr;67:155-67.

LP-211 (LP211)

生物&药学活性

物理化学性质&存储条件

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LP-211 (LP211)

生物&药学活性

物理化学性质&存储条件

参考文献

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